Oxígenoterapia en Prematuros

Dr Jorge Fabres

I.- Oxígeno en Reanimación

1. Vento Targeting Oxygen in Term and Preterm Infants Starting at Birth       https://pubmed.ncbi.nlm.nih.gov/31345541/

   Clin Perinatology 46 (2019) :  459 - 473

2. Ilcor   NLS  Task force   (neonatal)

   • 2022 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

   • Neonatal life support    (Ilcor neonatal)

3. Estudio To2rpido

   • Targeted Oxygen in the Resuscitation of Preterm Infants, a Randomized Clinical Trial

4. "certeza de evidencia " por grade

   • https://www.medwave.cl/revisiones/metodinvestreport/8109.html       Parte 1

   • https://www.medwave.cl/revisiones/metodinvestreport/8182.html       Parte 2

5. Welsford  M     Pediatrics 2019, 143 : e20181828

   • Initial Oxygen Use for Preterm Newborn Resuscitation: A Systematic Review With Meta-analysis

6. Wickoff  M       Circulation 2020, 142 (suplem 1 : s185

   • Neonatal Life Support: 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

7. Soar J               Resuscitation  2019, 145:95 - 150

   • 2019 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

8. Optimizing oxygen therapy for preterm infants at birth: Are we there yet?    

   • https://pubmed.ncbi.nlm.nih.gov/32044281/#affiliation-2

II.- Oxígeno en prematuro hospitalizado

1. "Neoprom"   Neonatal Oxigenation Prospective Meta - Analysis

   • Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration

   • Askie LM    Jama 2018 ; 319 (21) : 2190

     • Support

     • COT

     • Boost II UK

     • Boost II Australia

     • Boost II N Zelanda

2. Oxígeno en exceso =>  Metilación de ADN  =>   ¿ cáncer en edad posterior ?

III.- ¿ Qué recomendaciones se pueden hacer  ?

• FiO2 inicial en la reanimación de Prematuros

• Objetivos de saturación en prematuros